4-Fluoromethylphenidate (also known as 4-FMPH and 4F-MPH) is a stimulant compound that functions as a more active inhibitor of dopamine reuptake than methylphenidate, which is closely linked.
In order to determine their ability as anti-cocaine drugs, 4-Fluoromethylphenidate was further studied along with other (±)-threo-methylphenidate (TMP) analogues. 4F-MPH has been documented to have an ED50 mg / kg of 0.26 (0.18–0.36) and a relative methylphenidate potency of 3.33.
Another research found that meta- and para-substituted compounds with electron-withdrawing substituents appeared to have improved binding potency in the threo-isomers of methylphenidate. It has been stated that compounds containing fluorine, chlorine , bromine and methyl groups are more potent than methylphenidate. The following values were registered for 4F-MPH: [3H]WIN 35428 35.0 ± 3.0 binding (2) and [3H]dopamine 142 ± 2.0 binding (2).