Diclofensine (Ro 8-4650) CAS # 67165-56-4

Diclofensine (Ro 8-4650) CAS # 67165-56-4

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    In the 1970s, Hoffman-La Roche created Diclofensine (Ro 8-4650) in search of a new antidepressant. The (S) isomer has been found to be responsible for activity. It is a stimulant drug which acts as an inhibitor of triple monoamine reuptake, primarily inhibiting dopamine and norepinephrine reuptake. In human trials, it was found to be an effective antidepressant, with relatively few side effects, but was subsequently pulled from clinical development, likely because of concerns about its potential for violence.

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