Adrafinil (INN; brand name Olmifon) is a eugeroic that was previously used in France, particularly in the elderly, to promote alertness, concentration, wakefulness, mood, and other parameters. Individuals who preferred to prevent exhaustion, such as night workers or those who wanted to remain awake and alert for long periods of time, often used it off-label. “Adrafinil is often known to a broader non-scientific audience, where it is considered a nootropic agent.”
Adrafinil is a prodrug; it is mostly metabolized in vivo to modafinil, resulting in pharmacological effects which are quite close. However unlike modafinil, the metabolite takes time to accumulate to active levels in the bloodstream. Effects are usually evident on an empty stomach within 45-60 minutes when taken orally.