Methoxyketamine or 2-MeO-2-deschloroketamine is a designer drug first mentioned in 1963 for the arylcyclohexylamine class. It is a ketamine analog in which a methoxy group has been substituted for the chlorine atom. Its synthesis has been documented by rearranging an amino ketone. Methoxyketamine most likely acts as an antagonist of the NMDA receptor as arylcyclohexylamine. It can produce anesthetic effects that are sedative, hallucinogenic, and at high doses).